We present a rare case of a 77yearold caucasian female with metastasis from a cholangiocarcinoma to the oral floor contiguous with lingual gingival mucosa. The histopathological diagnosis of verrucous carcinoma should be accompanied with careful identification of tumors with a greater chance to become frank cancers. The most deadly aspect of cancer is its ability to spread, or metastasize. Diagnosis and treatment of cholangiocarcinoma boberg and schrumpf 53 ultrasonography ultrasonography is usually the first imaging procedure performed. Case report successful treatment of choriocarcinoma with.
A 54yearold woman consulted to our hospital because of mass of the left cheek next to the mandible. Human papillomavirus hpv detection in lip squamous cell carcinoma. More than 95% of these malignancies are cholangiocarcinomas epithelial adenocarcinomas frequently found in the extrahepatic biliary tree. A case of verrucous carcinoma, in oral cavity mucosa, with a previous history of defective prothesis and use of smokeless tobacco in a 60 year older white female. Pdf carcinoma verrugoso en paciente joven semantic scholar. It is a special form of welldifferentiated squamous cell carcinoma with specific clinical and. The author herein reports a case of multiple verrucous carcinomas vcs of the left lower gingiva. Carcinoma in situ in a patient with erythroleukoplakia. Verrucous carcinoma of the oral cavity international.
Cancer cells initially group together to form a primary tumor. The terms cholangiocarcinoma and bile duct cancer are often used interchangeably. Human papillomavirus hpv detection in lip squamous cell. Primary biliary tract malignancies affect one in every 100,000 people per year in the united states. Biopsy followed by microscopic examination revealed carcinoma in situ. The verrucous carcinoma is a low grade variant of oral squamous cell carcinoma, and it mostly appears in the oral mucosa of individuals who chew tobacco chronically 6, 8, 10. A total of 3,500 primary oral welldifferentiated squamous cell carcinoma surgically excised in the a. Case report successful treatment of choriocarcinoma with multiple organ metastases after term delivery.
Note the medialization of the lip as a result of using the labial mucosalsubmucosal flap for reconstruction of the intraoral defect. Here, we report quite a rare case in terms of long survivor after chemoradiotherapy on locally relapsed unresectable hilar cholangiocarcinoma. Central rii cellece i e ccess medical journal of obstetrics and gynecology cite this article. Oral verrucous carcinoma is a rare tumor first described by ackerman. The oral cavity is very unusual site of metastases even though wide spread metastatic disease may be present. Kalniev fellow, department of surgical oncology, university of texas m. J primary malignant melanoma of the oral cavity, cancer 11. Biopsy proven case of squamous cell carcinoma in right buccal mucosa. Anderson cancer center, houston, usa department of anatomy and cytology, medical university of. Figure 1 figure 1a above an oral melanoma in the maxilla of a dog. Oral floor and gingival metastasis of cholangiocarcinoma. Angiosarcoma of the oral cavity pubmed central pmc. Carcinoma verrucoso oral, radioterapia, paciente joven.
Since oel is considered a precancerous lesion with a high malignant transformation potential, the present case set out to discuss the challenges in diagnosing the condition and choosing the most appropriate treatment. Verrucous carcinoma vc is a rare oral tumor that is classified under carcinomas owing to characteristics that exists amid a benign verrucous lesion and. Vol 383 june 21, 2014 2169 cholangiocarcinoma mortality rates have increased by 39% because of increased disease incidence. Various names are used in the literature to describe this entity, including ackermans tumor, buschkeloewenstein tumor, florid oral papillomatosis, epithelioma cuniculatum, and carcinoma. Special emphasis is given to the importance of the clinical and histopathological diagnosis, in order to assure a correct treatment and good prognosis. Unusual presentation of pure ovarian choriocarcinomaa. The most common primary sites that metastasize to the oral cavity are lung, kidney, breast, and hepatocellular carcinoma. O carcinoma verrucoso ou carcinoma cutaneo papilomatoso, dependendo do local, recebe varias designacoes. A 78yearold man was admitted to our hospital because of gingival tumor. Oral verrucous carcinoma ovc is a rare variant of squamous cell carcinoma with a characteristic morphology and specific behavior. Each year, more than half a million people worldwide receive a diagnosis of hepatocellular carcinoma, and hepatocellular carcinoma related to hcv is the fastest rising cause of u.
Summary the general characteristics of melanocarcinoma of the buccal mucosa have been described, and a case of buccal melanocarcinoma with metastasis in the abdominal region has been reported. To date, few studies are available focusing the prevalence and clinicopathologic features of the oral verrucous carcinoma in brazilian population. New techniques of resection and longterm survival for cholangiocarcinoma ludmil m. Once the diagnosis has really been made, the percentage of cure is very small. This dog was treated with maxillectomy and carboplatin chemotherapy. Need for reappraisal of treatment abstract bone is an uncommon site of metastasis in patients with hepatocellular carcinoma hcc, and often overlooked. Dermis carcinoma verrucoso information on the diagnosis. Melanocarcinoma of the buccal mucosa sciencedirect. Whether the actual number in the lay public is increasing or whether this just appears to be the case because we are seeing more of them at the university medical center is hard to determine.
Figure 1b left appearance of the dog in figure 1a 2 weeks after maxillectomy. We report two cases that had isolated bone metastasis. Oral cancer is one of the major global threats to public health. Unknown, as with many translocation tumors, lesion tends to pursue a line of differentiation rather than originate from a particular line of derivation however, the tumor cells resemble clear cell rests of primitive dental lamina that are frequently in the same locations ghost cell odontogenic carcinoma. The known cases of oral metastasis involve patients who show oral symptoms while living. Oral verrucous carcinoma vc is a rare locally invasive tumor. Tambien es conocido como papilomatosis oral florida. The development of oral cancer is a tobaccorelated multistep and multifocal process involving field cancerization and carcinogenesis.
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